Re-mediating Ophelia with Pre-Raphaelite Eyes

Ophelia syndrome: Hodgkin lymphoma with limbic encephalitis.

BACKGROUND Limbic encephalitis, an immune-mediated encephalitis, results from inflammation in the medial temporal lobes. The paraneoplastic form is rare in pediatric population, and frequently precedes tumor diagnosis. CASE CHARACTERISTICS A 9-year-old boy receiving chemotherapy for Hodgkin lymphoma, developed headache, temporal lobe seizures, anxiety, hallucinations, short-term memory loss a...

The Ophelia Traceability Layer

Assessing the impact of change on a software development project is a critical management activity. Traceability affords us opportunities to manage the change process through notification and synchronisation mechanisms. We present an architecture, developed as part of the EU funded Ophelia project, that supports traceability across all project artefacts.

Re-Mediating Current Activity for the Future

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Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF.

Detection of Pre-Malifnant B-1 Cells in NZB Mice with a Re-stricted CDR3/DFL16 Region

The relationship between the immunoglobulin (Ig) nucleotide sequence and the ability of a B cell to develop into a malignant cell was studied in a subset of B cells, B-1 cells. B-1 cells become malignant in chronic lymphocytic leukemia (CLL) and are responsible for the production of "natural autoanti‌bodies". The autoimmune NZB mouse has been known as a human malignancy and CLL model, be‌cause ...